用于前交叉韧带重建的生物可降解带袢锌板的体外性能

王婷; 石章智; 钟宏勇; 李相民; 孙金岭; 殷唯; 纪晓静; 王强; 赵安琪; 王鲁宁

doi:10.1007/s12613-024-2889-5

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文章导航 > 矿物冶金与材料学报（英文） > 2024 > 一校

Ting Wang, Zhangzhi Shi, Hongyong Zhong, Xiangmin Li, Jinling Sun, Wei Yin, Xiaojing Ji, Qiang Wang, Anqi Zhao, and Luning Wang, In vitro performance of a biodegradable zinc alloy adjustable-loop cortical suspension fixation for anterior cruciate ligament reconstruction, Int. J. Miner. Metall. Mater.,(2024). https://doi.org/10.1007/s12613-024-2889-5

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Ting Wang, Zhangzhi Shi, Hongyong Zhong, Xiangmin Li, Jinling Sun, Wei Yin, Xiaojing Ji, Qiang Wang, Anqi Zhao, and Luning Wang, In vitro performance of a biodegradable zinc alloy adjustable-loop cortical suspension fixation for anterior cruciate ligament reconstruction, Int. J. Miner. Metall. Mater.,(2024). https://doi.org/10.1007/s12613-024-2889-5

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研究论文

用于前交叉韧带重建的生物可降解带袢锌板的体外性能

北京科技大学材料科学与工程学院, 北京 100083, 中国

通讯作者:
赵安琪 E-mail: zhaoanqi@ustb.edu.cn

王鲁宁 E-mail: luning.wang@ustb.edu.cn

文章亮点

(1) 首次设计并制备出用于前交叉韧带重建的可降解带袢锌板。

(2) 浸泡35天后，带袢锌板均匀降解，并能保持较高的固定强度。

(3) 锌合金浸提液能显著促进MC3T3-E1细胞的增殖和分化，并表现出卓越的抗菌性能。

中文摘要

膝关节前交叉韧带（ACL）损伤是最常见且严重的运动损伤之一，皮质悬吊固定是重建韧带移植物时常用的股骨固定方法。然而，广泛用于韧带重建的皮质悬吊带袢板仍为不锈钢、钛合金等永久性金属，由于长期存在于体内，可能会诱发慢性炎症，且在受伤组织愈合后需要进行第二次手术移除。本研究通过热挤压制备出可降解Zn–0.45Mn–0.2Mg（ZMM42）合金，屈服强度为300.4 MPa，抗拉强度为329.8 MPa，断裂延伸率为17.6%。并且，首次提出设计用于前交叉韧带重建的可调节袢锌合金皮质悬吊带袢板（带袢锌板）。在模拟体液中浸泡35天后，ZMM42带袢锌板整体均匀降解，降解速率稳定在43 μm/a。同时，35天后ZMM42带袢锌板与牵引线的固定强度仍能达到379 N。另外，ZMM42带袢锌板能显著促进MC3T3-E1细胞的增殖和成骨分化，并对大肠杆菌和金黄色葡萄球菌表现出很高的抗菌性。以上结果揭示了可降解锌合金在韧带修复临床应用中的巨大潜力，为未来开发多样化锌合金带袢锌板奠定了基础。

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Research Article

In vitro performance of a biodegradable zinc alloy adjustable-loop cortical suspension fixation for anterior cruciate ligament reconstruction

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Abstract

Abstract

Anterior cruciate ligament (ACL) injuries of the knee are one of the most common and serious athletic injuries. The widely used cortical suspension fixation buttons for ligament reconstruction are permanent implants, particularly those made from conventional steel or titanium alloys. In this study, a biodegradable Zn–0.45Mn–0.2Mg (ZMM42) alloy with the yield strength of 300.4 MPa and tensile strength of 329.8 MPa was prepared through hot extrusion. The use of zinc alloys in the preparation of cortical suspension fixation buttons was proposed for the first time. After 35 d of immersion in simulated body fluids, the ZMM42 alloy fixation buttons were degraded at a rate of 44 μm/a, and the fixation strength was retained (379.55 N) in the traction loops. Simultaneously, the ZMM42 alloy fixation buttons exhibited an increase in MC3T3-E1 cell viability and high antibacterial activity against Escherichia coli and Staphylococcus aureus. These results reveal the potential of biodegradable zinc alloys for use as ligament reconstruction materials and for developing diverse zinc alloy cortical suspension fixation devices.
- anterior cruciate ligament reconstruction;
- zinc alloy fixation buttons;
- mechanical property;
- corrosion behavior;
- biocompatibility

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