C60 High Performance Concrete (HPC) was prepared by limiting cement content and adopting composite superplasticizer, low-alkalinity expansive agent and high-quality line mixture. The results showed that the performance of the prepared C60 HPC was excellent. By adopting some advanced construction techniques such as using secondary vibration and secondary face compaction, controlling temperature difference and paying special attention to early curing in the construction process, the prepared C60 HPC had been successfully applied in the monolithic structure of huge building.