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Volume 11 Issue 6
Dec.  2004
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Lequan Minand Xisong Dong, Research on viral dynamic models of hepatitis B virus infection, J. Univ. Sci. Technol. Beijing, 11(2004), No. 6, pp. 572-576.
Cite this article as:
Lequan Minand Xisong Dong, Research on viral dynamic models of hepatitis B virus infection, J. Univ. Sci. Technol. Beijing, 11(2004), No. 6, pp. 572-576.
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Communication

Research on viral dynamic models of hepatitis B virus infection

  • 通讯作者:

    Lequan Min    E-mail: lqmin@sohu.com

  • A mathematical model with cytotoxic cells of hepatitis B virus (HBV) infection is set up based on a basic model of virus dynamics without cytotoxic cells and experimental observation of anti-viral drug therapy for HBV infection patients. A quantitative analysis of dynamic behaviors shows that the model has three kinds of equilibrium points, which represent the patient's complete recovery without immune ability, complete recovery with immune ability, and HBV persistent infection at the end of the treatment with drug lamivudine, respectively. Our model may provide possible quantitative interpretations for the treatments of chronic HBV infections with the drug lamivudine, in particularly explain why the plasma virus of Nowak et al.'s patients turnover the original level after stopping the lamivudine treatment.
  • Communication

    Research on viral dynamic models of hepatitis B virus infection

    + Author Affiliations
    • A mathematical model with cytotoxic cells of hepatitis B virus (HBV) infection is set up based on a basic model of virus dynamics without cytotoxic cells and experimental observation of anti-viral drug therapy for HBV infection patients. A quantitative analysis of dynamic behaviors shows that the model has three kinds of equilibrium points, which represent the patient's complete recovery without immune ability, complete recovery with immune ability, and HBV persistent infection at the end of the treatment with drug lamivudine, respectively. Our model may provide possible quantitative interpretations for the treatments of chronic HBV infections with the drug lamivudine, in particularly explain why the plasma virus of Nowak et al.'s patients turnover the original level after stopping the lamivudine treatment.
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