Abstract: Mine dust is classified as one of five natural coal mining disasters because it can harm the health of miners and poses a serious threat to the safety of the coal mine. Therefore, preparation of an effective dust suppression agent is highly desired. To improve the capture efficiency of fine dust, this study examines the dust suppression effects of various combinations of wetting agents, additives, and coagulation agents by using the optimum seeking method to reduce mine dust, particularly respirable particles. The optimal formula is shown to contain 10wt% fatty alcohol polyoxyethylene ether (JFC), 4.96wt% cationic polyacrylamide, and 4wt% calcium chloride. The dust suppression effect can be achieved at 96.1% in 5 min by using the optimal formula.