Jing Zhan, Qiao-jie Luo, Ying Huang, and Xiao-dong Li, Cellular response to titanium discs coated with polyelectrolyte multilayer films, Int. J. Miner. Metall. Mater., 21(2014), No. 9, pp. 925-933. https://doi.org/10.1007/s12613-014-0991-9
Cite this article as:
Jing Zhan, Qiao-jie Luo, Ying Huang, and Xiao-dong Li, Cellular response to titanium discs coated with polyelectrolyte multilayer films, Int. J. Miner. Metall. Mater., 21(2014), No. 9, pp. 925-933. https://doi.org/10.1007/s12613-014-0991-9
Jing Zhan, Qiao-jie Luo, Ying Huang, and Xiao-dong Li, Cellular response to titanium discs coated with polyelectrolyte multilayer films, Int. J. Miner. Metall. Mater., 21(2014), No. 9, pp. 925-933. https://doi.org/10.1007/s12613-014-0991-9
Citation:
Jing Zhan, Qiao-jie Luo, Ying Huang, and Xiao-dong Li, Cellular response to titanium discs coated with polyelectrolyte multilayer films, Int. J. Miner. Metall. Mater., 21(2014), No. 9, pp. 925-933. https://doi.org/10.1007/s12613-014-0991-9
The purpose of this study was to investigate the effects of polyelectrolyte multilayer (PEM) coatings on the biological behavior of titanium (Ti) substrates. Collagen type Ι/hyaluronic acid (Col/HA) and chitosan/hyaluronic acid (Chi/HA) multilayer PEM coatings were introduced onto Ti substrates using layer-by-layer assembly. Contact angle instruments and quartz crystal microbalance were used for film characterization. The results obtained showed that both Col/HA and Chi/HA surfaces had high hydrophilicity and promoted cell adhesion in MC3T3-E1 pre-osteoblast and human gingival fibroblast cells. In addition, the synthesis of function-related proteins and gene expression levels in both MC3T3-E1 and fibroblast cells was higher for the Col/HA coating compared with the Chi/HA coating, indicating better cellular response to the Col/HA coating.
The purpose of this study was to investigate the effects of polyelectrolyte multilayer (PEM) coatings on the biological behavior of titanium (Ti) substrates. Collagen type Ι/hyaluronic acid (Col/HA) and chitosan/hyaluronic acid (Chi/HA) multilayer PEM coatings were introduced onto Ti substrates using layer-by-layer assembly. Contact angle instruments and quartz crystal microbalance were used for film characterization. The results obtained showed that both Col/HA and Chi/HA surfaces had high hydrophilicity and promoted cell adhesion in MC3T3-E1 pre-osteoblast and human gingival fibroblast cells. In addition, the synthesis of function-related proteins and gene expression levels in both MC3T3-E1 and fibroblast cells was higher for the Col/HA coating compared with the Chi/HA coating, indicating better cellular response to the Col/HA coating.
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