Abstract:
Porous magnesium strontium phosphate (Sr
3−xMg
x(PO
4)
2) (
x = 2, 2.5, 3) composite scaffolds were successfully prepared by three dimension gel-printing (3DGP) method in this study. The results show that Sr
0.5Mg
2.5(PO
4)
2 scaffolds had good compressive strength, and Sr
1.0Mg
2.0(PO
4)
2 scaffolds had good degradation rate
in vitro. The weight loss rate of Sr
1.0Mg
2.0(PO
4)
2 scaffolds soaked in simulated body fluid (SBF) or 6 weeks was 6.96%, and pH value varied between 7.50 and 8.61, which was within the acceptable range of human body. Preliminary biological experiment shows that MC3T3-E1 cells had good adhesion and proliferation on the surface of Sr
3−xMg
x(PO
4)
2 scaffolds. Compared with pure Mg
3(PO
4)
2 scaffolds, strontium doped scaffolds had excellent comprehensive properties, which explain that Sr
3−xMg
x(PO
4)
2 composite scaffolds can be used for bone tissue engineering.