Abstract: Organic contaminants have posed a direct and substantial risk to human wellness and the environment. In recent years, piezoelectric catalysis has evolved as a novel and effective method for decomposing these contaminants. Although piezoelectric materials offer a wide range of options, most related studies thus far have focused on inorganic materials and have paid little attention to organic materials. Organic materials have advantages, such as being lightweight, inexpensive, and easy to process, over inorganic materials. Therefore, this paper provides a comprehensive review of the progress made in the research on piezoelectric catalysis using organic materials, highlighting their catalytic efficiency in addressing various pollutants. In addition, the applications of organic materials in piezoelectric catalysis for water decomposition to produce hydrogen, disinfect bacteria, treat tumors, and reduce carbon dioxide are presented. Finally, future developmental trends regarding the piezoelectric catalytic potential of organic materials are explored.