Abstract: Slurry electrolysis (SE), as a hydrometallurgical process, has the characteristic of a multitank series connection, which leads to various stirring conditions and a complex solid suspension state. The computational fluid dynamics (CFD), which requires high computing resources, and a combination with machine learning was proposed to construct a rapid prediction model for the liquid flow and solid concentration fields in a SE tank. Through scientific selection of calculation samples via orthogonal experiments, a comprehensive dataset covering a wide range of conditions was established while effectively reducing the number of simulations and providing reasonable weights for each factor. Then, a prediction model of the SE tank was constructed using the K-nearest neighbor algorithm. The results show that with the increase in levels of orthogonal experiments, the prediction accuracy of the model improved remarkably. The model established with four factors and nine levels can accurately predict the flow and concentration fields, and the regression coefficients of average velocity and solid concentration were 0.926 and 0.937, respectively. Compared with traditional CFD, the response time of field information prediction in this model was reduced from 75 h to 20 s, which solves the problem of serious lag in CFD applied alone to actual production and meets real-time production control requirements.