Cite this article as:

Xinyi Zhou, Jun Cheng, Jun Xu, Yipei Mao, Yang Dong, Yixuan He, and Meifeng He, Effect of low Zn content on corrosion resistance and biocompatibility of biodegradable Mg–Zn–Y–Zr alloys, Int. J. Miner. Metall. Mater., (2025). https://doi.org/10.1007/s12613-025-3092-z
Xinyi Zhou, Jun Cheng, Jun Xu, Yipei Mao, Yang Dong, Yixuan He, and Meifeng He, Effect of low Zn content on corrosion resistance and biocompatibility of biodegradable Mg–Zn–Y–Zr alloys, Int. J. Miner. Metall. Mater., (2025). https://doi.org/10.1007/s12613-025-3092-z
引用本文 PDF XML SpringerLink

低锌含量对可生物降解Mg–Zn–Y–Zr合金耐蚀性和生物相容性的影响

摘要: 虽然镁合金的可降解性和生物安全性使其在生物应用中具有优势,但由镁合金制成的医疗植入物往往因腐蚀而过早失效。因此,提高镁合金的耐腐蚀性能成为合金设计过程中亟待解决的问题。本研究设计并制备了热挤压状态下的Mg–xZn–0.5Y–0.5Zr合金 (x = 1, 2, 3, wt%),并通过扫描电镜、能谱分析和x射线衍射分析了其表面结构。结果表明,Zn含量的增加使合金中的再结晶晶粒细化。特别是在Mg–3Zn–0.5Y–0.5Zr中,I相变得更细,形成粒状和纳米针状颗粒。浸泡实验后的表面表征表明,腐蚀产物层主要由Mg(OH)2、Zn(OH)2、CaCO3和羟基磷灰石组成。采用析氢法和失重法测量合金的腐蚀速率,ZW305K的降解速率最低,分别为4.1和6.0 mm/a。电化学实验进一步解释了该合金在溶液中的腐蚀回路模型,证实了之前的结果。ZW305K的最大极化电阻为874.5 Ω,最小腐蚀电流密度为0.104 mA/cm2。作为生物医学合金,必须表现出良好的生物相容性,因此该合金还通过细胞毒性、细胞粘附、染色实验进行了测试。锌的加入增强了合金的生物相容性,48h后各组细胞活力均大于80%。

 

Effect of low Zn content on corrosion resistance and biocompatibility of biodegradable Mg–Zn–Y–Zr alloys

Abstract: Although the degradability and biosafety of magnesium alloys make them advantageous for biological applications, medical implants made of magnesium alloys often fail prematurely due to corrosion. Therefore, improving the corrosion resistance of magnesium alloys has become an urgent problem in the alloy design process. In this study, we designed and prepared Mg–xZn–0.5Y–0.5Zr (x = 1, 2, and 3, wt%) alloys in a hot extruded state and analyzed their surface structure through scanning electron microscopy, energy dispersion spectrometry, and X-ray diffraction. It was found that increasing the Zn content refined the recrystallized grains in the alloy. Particularly in Mg–3Zn–0.5Y–0.5Zr, the I phase became finer, forming both granular and nanoscale needle-like particles. Surface characterization after the immersion experiment showed that the corrosion product layer was mainly composed of Mg(OH)2, Zn(OH)2, CaCO3, and hydroxyapatite. The degradation rate of ZW305K was the lowest, measured as 4.1 and 6.0 mm/a with the hydrogen precipitation method and weight loss method respectively. Electrochemical experiments further explained the corrosion circuit model of the alloy in solution and confirmed the earlier results. The maximum polarization resistance of ZW305K was 874.5 Ω·cm2, and the lowest corrosion current density was 0.104 mA/cm2. As a biomedical alloy, it must exhibit good biocompatibility, so the alloy was also tested through cytotoxicity, cell adhesion, and staining experiments. The cell viability of each group after 48 h was greater than 80%, showing that the addition of zinc enhances the alloy’s biocompatibility. In summary, the prepared alloys have the potential to be used as biodegradable implant materials.

 

/

返回文章
返回