The influence of three important operation parameters in Jinlong flash smelting furnace, including the distributing blast speed, the oxygen enrichment rate of process air and the ratio of central oxygen to overall oxygen (O_c/O_o), has been investigated using a virtual simulation system on copper flash smelting furnace. The core of this virtual simulation system is a numerical simulation of CFD (computational fluid dynamics), and this system incorporates coupling momentum transport, heat transport, mass transport,reaction kinetics between gas and particles and chemical reactions between gas and gas. A set of numerical predicted data were obtained. The CFD simulation shows that there is a sensitive zone of the distributing blast speed, and the dust content ascends when the speed exceeds 180 m·s^-1. Increasing the oxygen concentration of processing air benefits the efficient production of the flash smelting furnace.